CliniPhenome

A database for clinical and phenotypic data processing.

VUB (UZ Brussels in collaboration with AI Lab) has developed, a PHP based application coupled to a MySQL database application, for collection of data for patient's being analyzed for Cardiac Arrhythmia Syndrome. However, the database schema has been designed in a generalized form, keeping in consideration to be used for other disease also. The application has been named as "CliniPhenome", as it would store clinical and phenotypic measures for a patient.

CliniPhenome features streamlining of clinical workflow, efficient data entry and retrieval, improved diagnosis, cross-referencing of patient phenotype with clinical annotation, and sharing of de-identified patient data for research purposes.

CliniPhenome has a generalized clinical schema design along with a merged ontology schema that provides cross-referencing possibilities and supports for clinical and phenotypic annotation for patients. The controlled vocabulary and data structure of CliniPhenome answers for the prevalent problem of plain text storage in the existing clinical databases, which causes impediment during data analysis. CliniPhenome not only supports the collection of patient data but also phenotypic and clinical annotation. Phenotypic annotation is supported by autogenously designed ontology that supports for Human Phenotype Ontology (HPO), Online Mendelian Inheritance in Man (OMIM) and Orphanet. Clinical annotation is currently supported by SNOMED and LOINC, with eventual assimilation of ICD-10 into it. It is a PHP based application with an easily operated interface that runs on a web browser and is facilitated by a MySQL database. A generalized schema design has been proposed, that ensures improved empathy among clinicians and researchers. Besides, it also features data migration utility, that supports exchange of de-identified data in XML or JSON structure among the collaborators.



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